Article
TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver.
Blood - 1 Mar 2005
Takeda Kazuyoshi, Cretney Erika, Hayakawa Yoshihiro, Ota Tsuyoshi, Akiba Hisaya, Ogasawara Kouetsu, Yagita Hideo, Kinoshita Katsuyuki, Okumura Ko, Smyth Mark J
Abstract excerpt
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a key effector molecule expressed by natural killer (NK) cells and has been shown to prevent tumor initiation, growth, and metastasis. Here we demonstrate that TRAIL is the dominant cytotoxic effector molecule expressed by NK cells in fetal mice. On birth and with age, NK cells develop full functional capacity, including the ability to...
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