Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FoxO1-mediated autophagy is required for NK cell development and innate immunity.

Nature communications - 24 Mar 2016

Wang Shuo, Xia Pengyan, Huang Guanling, Zhu Pingping, Liu Jing, Ye Buqing, Du Ying, Fan Zusen

Abstract excerpt

Natural killer (NK) cells exert a crucial role in early immune responses as a major innate effector component. However, the underlying mechanisms of NK cell development remain largely elusive. Here we show that robust autophagy appears in the stage of immature NK cells (iNKs), which is required for NK cell development. Autophagy defects result in damaged mitochondria and accumulation of reactive oxygen species...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Cytoprotection
Share to Cytosol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein O1

Share to Forkhead Transcription Factors

Share to Killer Cells, Natural

Share to Microtubule-Associated Proteins

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 27010363
DOI: 10.1038/ncomms11023
PMCID: PMC4820827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FoxO1-mediated autophagy is required for NK cell development and innate immunity.PMID 27010363Read ↗

Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature.Semantic proximity Read ↗

Invariant NKT cells require autophagy to coordinate proliferation and survival signals during differentiation.Semantic proximity Read ↗

Autophagy is essential for effector CD8+ T cell survival and memory formationSemantic proximity Read ↗

iNKT cells require TSC1 for terminal maturation and effector lineage fate decisionsSemantic proximity Read ↗

Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic CellsSemantic proximity Read ↗

Memory responses of innate lymphocytes and parallels with T cells.Semantic proximity Read ↗

Molecular Regulation of NK Cell Maturation.Semantic proximity Read ↗

TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver.Semantic proximity Read ↗

Biallelic mutations in IRF8 impair human NK cell maturation and function.Semantic proximity Read ↗

TREM2 Promotes Natural Killer Cell Development in CD3-CD122+NK1.1+ pNK CellsSemantic proximity Read ↗

Survival of Effector CD8+ T Cells during Influenza Infection Is Dependent on AutophagySemantic proximity Read ↗

Natural killer cell development and maturation in aged mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.