Human homolog of Drosophila tumor suppressor Scribble negatively regulates cell‐cycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells

Abstract excerpt

Drosophila tumor suppressor Scribble has been identified as an apical-basolateral polarity determinant in epithelia. A human homolog of Drosophila Scribble, human Scribble (hScrib), has been identified as a protein targeted by human papillomavirus E6 for the ubiquitin-mediated degradation dependent on E6AP, a cellular ubiquitin-protein ligase. Human Scribble is classified as a LAP protein, having leucine-rich...

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