Article
Radiation-induced chromosomal instability and gene expression profiling: searching for clues to initiation and perpetuation.
Mutation research - 2 Dec 2004
Snyder Andrew R, Morgan William F
Abstract excerpt
Radiation-induced genomic instability (RIGI) manifests in the progeny of cells surviving ionizing radiation (IR), and can be measured using such endpoints as delayed mutation, micronuclei formation, and chromosomal instability. The frequency of RIGI is relatively high, exceeding the gene mutation rate of IR by orders of magnitude, leading to conjecture that a gene mutation is not the cause of the phenotype. We...
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