Article
Which complement assays and typings are necessary for the diagnosis of complement deficiency in patients with lupus erythematosus? A study of 25 patients.
Clinical immunology (Orlando, Fla.) - 1 Nov 2006
Boeckler P, Meyer A, Uring-Lambert B, Goetz J, Cribier B, Hauptmann G, Lipsker D
Abstract excerpt
INTRODUCTION: Deficiencies in components of the classical pathway of complement activation are strong risk factors for lupus erythematosus (LE).Yet, it has not been addressed whether the conventional measurements of the serum hemolytic CH50 activity and antigenic concentrations of C3 and C4 are sufficient to asses a deficiency in C4A, C4B or C2 components, the most common deficiencies associated with LE. PATIENTS...
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