Lipopolysaccharide‐induced expression of multiple alternatively spliced <i>MEFV</i> transcripts in human synovial fibroblasts: A prominent splice isoform lacks the C‐terminal domain that is highly mutated in familial mediterranean fever

Abstract excerpt

OBJECTIVE: To investigate the expression of the familial Mediterranean fever (FMF) gene (MEFV) in human synovial fibroblasts. METHODS: MEFV messenger RNA in synovial fibroblasts, chondrocytes, and peripheral blood leukocytes (PBLs) was analyzed by semiquantitative and real-time polymerase chain reaction and ribonuclease protection assay. The subcellular localization of pyrin, the MEFV product, was determined in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Immune Cell Function and Interaction
• Share to Inflammasome and immune disorders