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Article

Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium.

Cell - 22 Aug 1997

Abstract excerpt

Familial Mediterranean fever (FMF) is a recessively inherited disorder characterized by dramatic episodes of fever and serosal inflammation. This report describes the cloning of the gene likely to cause FMF from a 115-kb candidate interval on chromosome 16p. Three different missense mutations were identified in affected individuals, but not in normals. Haplotype and mutational analyses disclosed ancestral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 9288758
DOI: 10.1016/s0092-8674(00)80539-5

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