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Article

Genetic susceptibility to diabetic kidney disease is linked to promoter variants of XOR.

Nature metabolism - 1 Apr 2023

Wang Qin, Qi Haiying, Wu Yiming, Yu Liping, Bouchareb Rihab, Li Shuyu, Lassén Emelie, Casalena Gabriella, Stadler Krisztian, Ebefors Kerstin, Yi Zhengzi, Shi Shaolin, Salem Fadi, Gordon Ronald, Lu Lu, Williams Robert W, Duffield Jeremy, Zhang Weijia, Itan Yuval, Böttinger Erwin, Daehn Ilse

Abstract excerpt

The lifetime risk of kidney disease in people with diabetes is 10-30%, implicating genetic predisposition in the cause of diabetic kidney disease (DKD). Here we identify an expression quantitative trait loci (QTLs) in the cis-acting regulatory region of the xanthine dehydrogenase, or xanthine oxidoreductase (Xor), a binding site for C/EBPβ, to be associated with diabetes-induced podocyte loss in DKD in male mice....

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Identifiers

PMID: 37024752
DOI: 10.1038/s42255-023-00776-0
PMCID: PMC10821741

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