Article
A link between mRNA turnover and RNA interference in Arabidopsis.
Science (New York, N.Y.) - 5 Nov 2004
Gazzani S, Lawrenson T, Woodward C, Headon D, Sablowski R
Abstract excerpt
In RNA interference (RNAi), double-stranded RNA (dsRNA) triggers degradation of homologous messenger RNA. In many organisms, RNA-dependent RNA polymerase (RdRp) is required to initiate or amplify RNAi, but the substrate for dsRNA synthesis in vivo is not known. Here, we show that RdRp-dependent transgene silencing in Arabidopsis was caused by mutation of XRN4, which is a ribonuclease (RNase) implicated in mRNA...
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