Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in C57BL/6J x RR F2 mice.

doi:10.1023/b:bigi.0000039809.40228.d3

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Article

Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in C57BL/6J x RR F2 mice.

Biochemical genetics - 1 Oct 2004

Suto Jun-ichi, Takahashi Yuji, Sekikawa Kenji

Abstract excerpt

A highly significant cholesterol quantitative trait locus (QTL) (Cq6) was identified on chromosome 1 in C57BL/6J x RR F2 mice. The Cq6 was located over the gene for apolipoprotein A-Il (Apoa2), and the RR allele was associated with increased plasma cholesterol. C57BL/6J has Apoa2a alleles and RR has Apoa2b alleles. Three different Apoa2 alleles are known on the basis of amino acid substitutions at four residues....

Topics

Alleles
Amino Acid Sequence
Amino Acid Substitution
Animals
Apolipoprotein A-II
Cholesterol
Chromosomes
Crosses, Genetic
Genetic Linkage
Mice
Molecular Sequence Data
Polymorphism, Genetic
Quantitative Trait Loci
Triglycerides

Source

Open in PubMed

Identifiers

PMID: 15524312
DOI: 10.1023/b:bigi.0000039809.40228.d3

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