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Article

Klotho gene variation and expression in 20 inbred mouse strains.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2004

Bektas Arsun, Schurman Shepherd H, Sharov Alexei A, Carter Mark G, Dietz Harry C, Francomano Clair A

Abstract excerpt

A defect in klotho gene expression in the mouse results in a syndrome that resembles human aging, with greatly shortened lifespan, arteriosclerosis, and defective hearing. In an effort to find functional murine variants of klotho, we sequenced the gene and examined renal expression of the secrete...

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PMID: 15520879
DOI: 10.1007/s00335-004-2375-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15520879-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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