Article
Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk.
The Journal of biological chemistry - 20 Dec 2013
Tucker Zhou Tracey B, King Gwendalyn D, Chen CiDi, Abraham Carmela R
Abstract excerpt
Klotho (KL) is an age-regulating protein named after the Greek goddess who spins the thread of life. Mice deficient in KL are normal throughout development, but rapidly degenerate and display a variety of aging-associated abnormalities that eventually lead to decreased life expectancy. While multiple genetic association studies have identified KL polymorphisms linked with changes in disease risk, there is a...
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