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Article

Doxepin inhibits CYP2D6 activity in vivo.

Polish journal of pharmacology - 1 Jan 2000

Szewczuk-Bogusławska Monika, Kiejna Andrzej, Beszłej Jan A, Orzechowska-Juzwenko Krystyna, Milejski Piotr

Abstract excerpt

OBJECTIVE: Doxepin is a tricyclic antidepressant formulated as a mixture of E-(trans) and Z-(cis) stereoisomers. Cytochrome P450 2D6 (CYP2D6) catalyzes the hydroxylation of E-doxepin and E-N-desmethyldoxepin stereospecically. There is evidence that tricyclic antidepressants might inhibit CYP2D6 activity but there is no data about the influence of doxepin on CYP2D6. MATERIALS AND METHODS: Eleven patients diagnosed...

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PMID: 15520506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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