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Article

Polymorphic hydroxylation of perhexiline in vitro.

British journal of clinical pharmacology - 1 Jun 2003

Sørensen L B, Sørensen R N, Miners J O, Somogyi A A, Grgurinovich N, Birkett D J

Abstract excerpt

AIMS: The aims of this study were to examine the in vitro enzyme kinetics and CYP isoform selectivity of perhexiline monohydroxylation using human liver microsomes. METHODS: Conversion of rac-perhexiline to monohydroxyperhexiline by human liver microsomes was assessed using a high-performance liquid chromatography assay with precolumn derivatization to measure the formation rate of the product. Isoform selective...

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Source

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Identifiers

PMID: 12814462
DOI: 10.1046/j.1365-2125.2003.01805.x
PMCID: PMC1884253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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