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Article

Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line.

Nucleic acids research - 1 Nov 2004

Thomas Heike, Senkel Sabine, Erdmann Silke, Arndt Tanja, Turan Gülüzar, Klein-Hitpass Ludger, Ryffel Gerhart U

Abstract excerpt

Using the rat insulinoma cell line INS-1 we generated beta-cell clones that are most efficient for gene transfer, as they contain an FRT site for Flp recombinase-mediated, site-directed integration of a single copy transgene. Therefore, the gene-of-interest can be introduced by DNA transfection w...

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PMID: 15520459
DOI: 10.1093/nar/gnh144
PMCID: PMC528820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15520459-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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