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Article

Auditory-conditioned-fear-dependent c-Fos expression is altered in the emotion-related brain structures of Fyn-deficient mice.

Brain research. Molecular brain research - 4 Nov 2004

Kubota Osamu, Hattori Kotaro, Hashimoto Kenji, Yagi Takeshi, Sato Toshio, Iyo Masaomi, Yuasa Shigeki

Abstract excerpt

Fyn-tyrosine-kinase-deficient mice exhibit increased fearfulness. To elucidate the neural mechanisms of their emotional defects, we compared fyn(-/-) and fyn(+/-) mice by behavioral analysis of conditioned fear and by functional neuroanatomical analysis of the distribution of highly responsive neurons associated with conditioned fear. The mice were exposed to the auditory conditioned stimulus paired with electric...

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Identifiers

PMID: 15519685
DOI: 10.1016/j.molbrainres.2004.07.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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