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Article

Bone Mineral Density in Sclerosteosis; Affected Individuals and Gene Carriers

1 Dec 2005

Abstract excerpt

BACKGROUND: Sclerosteosis is an autosomal recessive sclerosing bone disorder due to deficiency of sclerostin, a protein secreted by the osteocytes that inhibits bone formation. In the present study we assessed the effect of variable expression of the genetic defect on bone mineral density (BMD) in patients and carriers of the determinant gene. METHODS: We studied 25 individuals (seven patients and 18...

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Identifiers

PMID: 16189254
DOI: 10.1210/jc.2005-1235

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