Article
Increased cytochrome P450 17alpha-hydroxylase promoter function in theca cells isolated from patients with polycystic ovary syndrome involves nuclear factor-1.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2004
Wickenheisser Jessica K, Nelson-DeGrave Velen L, Quinn Patrick G, McAllister Jan M
Abstract excerpt
Cytochrome P450 17alpha-hydroxylase (CYP17) gene expression and androgen biosynthesis are persistently elevated in theca cells isolated from ovaries of women with polycystic ovary syndrome (PCOS). We previously reported that -235 to -109 bp of the CYP17 promoter confers increased CYP17 promoter function in PCOS theca cells. In this report, additional deletion and mutational analyses of the CYP17 promoter were...
Topics
- Adult
- Base Sequence
- Binding Sites
- CCAAT-Enhancer-Binding Proteins
- Cells, Cultured
- Female
- Gene Expression Regulation
- Humans
- Molecular Sequence Data
- Mutation
- NFI Transcription Factors
- Polycystic Ovary Syndrome
- Promoter Regions, Genetic