Article
USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts.
The American journal of pathology - 1 Nov 2004
Oliveira Andre M, Perez-Atayde Antonio R, Inwards Carrie Y, Medeiros Fabiola, Derr Victoria, Hsi Bae-Li, Gebhardt Mark C, Rosenberg Andrew E, Fletcher Jonathan A
Abstract excerpt
Aneurysmal bone cyst (ABC) is a locally recurrent bone lesion that has been regarded as a reactive process. Recently, a neoplastic basis in primary ABC was evidenced by demonstration of clonal chromosome band 17p13 translocations that place the USP6 (TRE2 or TRE17) oncogene under the regulatory influence of the highly active CDH11 promoter. Herein, we report CDH11 and/or USP6 rearrangements in 36 of 52 primary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.