Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Jak1–STAT3 Signals Are Essential Effectors of the USP6/TRE17 Oncogene in Tumorigenesis

20 Jul 2016

Abstract excerpt

Bone and soft tissue tumors (BSTT) are relatively poorly understood, hampering the development of effective therapies. Here we report a role for the ubiquitin-specific protease 6 (USP6)/TRE17 oncogene, which is overexpressed upon chromosome translocation in various human tumors, including aneurysmal bone cyst (ABC), and the related benign lesion nodular fasciitis. Ectopic expression of USP6 is known to drive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Sarcoma Diagnosis and Treatment
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27440725
DOI: 10.1158/0008-5472.can-15-2391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Jak1–STAT3 Signals Are Essential Effectors of the USP6/TRE17 Oncogene in TumorigenesisPMID 27440725Read ↗

The TRE17 USP6 Oncogene a riddle wrapped in a mystery inside an enigmaSemantic proximity Read ↗

The TRE17/USP6 Oncogene: a riddle wrapped in a mystery inside an enigmaSemantic proximity Read ↗

Ubiquitin-specific Peptidase 6 (USP6)-associated Fibroblastic/Myofibroblastic Tumors: Evolving ConceptsSemantic proximity Read ↗

Novel ASAP1‐USP6, FAT1‐USP6, SAR1A‐USP6, and TNC‐USP6 fusions in primary aneurysmal bone cystSemantic proximity Read ↗

Novel and unusual USP6 fusion partners in aneurysmal bone cyst and their role in pathogenesis and histopathological evaluation of this diseaseSemantic proximity Read ↗

Spotlights on ubiquitin-specific protease 12 (USP12) in diseases: from multifaceted roles to pathophysiological mechanismsSemantic proximity Read ↗

USP8-Rearranged Mesenchymal Tumors With Myofibroblastic Phenotype: A Comprehensive Clinicopathologic, Genetic, and Epigenetic Characterization.Semantic proximity Read ↗

USP3 : Key deubiquitylation enzyme in human diseasesSemantic proximity Read ↗

Novel partners of USP6 gene in a spectrum of bone and soft tissue lesions.Semantic proximity Read ↗

Ubiquitin-specific peptidase 10, a deubiquitinating enzyme: Assessing its role in tumor prognosis and immune responseSemantic proximity Read ↗

<i>PPP6R3‐USP6</i> amplification: Novel oncogenic mechanism in malignant nodular fasciitisSemantic proximity Read ↗

WWP1 E3 ligase at the crossroads of health and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.