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Article

The TRE17/USP6 Oncogene: a riddle wrapped in a mystery inside an enigma

26 Oct 2011

Abstract excerpt

De-ubiquitinating enzymes (DUBs) play critical roles in diverse cellular processes, including intracellular trafficking, protein turnover, inflammatory signaling, and cell transformation. The first DUB to be identified as an oncogene was TRE17/Ubiquitin-specific protease 6 (USP6)/Tre-2. In addition to encoding a USP, TRE17 also contains a TBC (Tre-2/Bub2/Cdc16) domain implicated in GTPase regulation and...

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PMID: 22202063
DOI: 10.2741/271

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