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Article

Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice.

The American journal of pathology - 1 Nov 2004

Langui Dominique, Girardot Nadège, El Hachimi Khalid Hamid, Allinquant Bernadette, Blanchard Véronique, Pradier Laurent, Duyckaerts Charles

Abstract excerpt

In transgenic mice expressing human mutant beta-amyloid precursor protein (APP) and mutant presenilin-1 (PS1), Abeta antibodies labeled granules, about 1 microm in diameter, in the perikaryon of neurons clustered in the isocortex, hippocampus, amygdala, thalamus, and brainstem. The granules were present before the onset of Abeta deposits; their number increased up to 9 months and decreased in 15-month-old...

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Identifiers

PMID: 15509518
DOI: 10.1016/s0002-9440(10)63405-0
PMCID: PMC1618656

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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