Article
KIT gene deletions at the intron 10-exon 11 boundary in GI stromal tumors.
The Journal of molecular diagnostics : JMD - 1 Nov 2004
Corless Christopher L, McGreevey Laura, Town Ajia, Schroeder Arin, Bainbridge Troy, Harrell Patina, Fletcher Jonathan A, Heinrich Michael C
Abstract excerpt
Most gastrointestinal stromal tumors (GISTs) harbor oncogenic mutations in the KIT gene, and the majority of these mutations affect the juxtamembrane domain of the kinase encoded by exon 11. Screening GISTs for KIT gene mutations is important for translational research studies and for providing prognostic information on the likelihood of tumor response to treatment with the kinase inhibitor imatinib mesylate...
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