Article
Extracellular domain c-kit mutation with duplication of Ser501Ala502 found in gastrointestinal stromal tumors is more imatinib- and nilotinib-sensitive than that with duplication of Ala502Tyr503.
Laboratory investigation; a journal of technical methods and pathology - 1 May 2013
Liu Ning-Ning, Ohkouchi Mizuka, Hashikura Yuka, Kajimoto Noriko, Matsuda Ikuo, Isozaki Koji, Toh Yasushi, Takahashi Tsuyoshi, Nishida Toshirou, Hirota Seiichi
Abstract excerpt
The great majority of gastrointestinal stromal tumors (GISTs) have gain-of-function mutations of the c-kit gene, which encodes KIT receptor tyrosine kinase. Most of the mutations are located at exon 11, but some are at exon 9 or at other exons. Mutation types at exon 11 vary, while most mutations at exon 9 are a particular duplication of Ala502Tyr503 (KIT-Dup-Ala502Tyr503). Recently a duplication of Ser501Ala502...
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