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Article

KIT Exon 11 Codons 557-558 Deletion Mutation Promotes Liver Metastasis Through the CXCL12/CXCR4 Axis in Gastrointestinal Stromal Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2016

Wang Hao-Chen, Li Tzu-Ying, Chao Ying-Jui, Hou Ya-Chin, Hsueh Yuan-Shuo, Hsu Kai-Hsi, Shan Yan-Shen

Abstract excerpt

PURPOSE: KIT mutations, the most prevalent genetic event in gastrointestinal stromal tumors (GIST), are associated with malignant features and poor prognosis. Aggressive GISTs possess a high propensity to spread to the liver. This study aimed to explore the role of KIT mutations in GIST liver metastasis. EXPERIMENTAL DESIGN: A total of 170 GISTs were used to determine the association between KIT mutations and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-kit

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Source

Identifiers

PMID: 26936919
DOI: 10.1158/1078-0432.CCR-15-2748

Genes

KIT
CXCR4
ETV1
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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