Article
Exon 11 homozygous mutations and intron 10/exon 11 junction deletions in the KIT gene are associated with poor prognosis of patients with gastrointestinal stromal tumors.
Cancer medicine - 1 Sept 2020
Shen Yan-Ying, Ma Xin-Li, Wang Ming, Zhuang Chun, Ni Bo, Tu Lin, Liu Qiang, Zhao Wen-Yi, Cao Hui
Abstract excerpt
BACKGROUND: Gastrointestinal stromal tumors (GISTs) with different types of mutations exhibit different clinical characteristics and prognosis. This study aimed to evaluate the prognostic value of mutations in KIT and PDGFRA in a large-scale cohort of GIST patients with current therapy including surgery and imatinib. METHODS: A total of 1163 patients diagnosed with GISTs between January 2006 and December 2018...
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