Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered specificity of Hint-W123Q supports a role for Hint inhibition by ASW in avian sex determination.

Physiological genomics - 15 Dec 2004

Parks Kristen P, Seidle Heather, Wright Nathan, Sperry Jeffrey B, Bieganowski Pawel, Howitz Konrad, Wright Dennis L, Brenner Charles

Abstract excerpt

Hint is a universally conserved, dimeric AMP-lysine hydrolase encoded on the avian Z chromosome. Tandemly repeated on the female-specific W chromosome, Asw encodes a potentially sex-determining, dominant-negative Hint dimerization partner whose substrate-interacting residues were specifically altered in evolution. To test the hypothesis that Gln127 of Asw is responsible for depression and/or alteration of Hint...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Monophosphate
Share to Aniline Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Avian Proteins

Share to Expressed Sequence Tags

Share to Glutamine

Share to Hydrolases

Share to Sex Chromosomes

Share to Sex Determination Processes

Source

Open in PubMed Open full text

Identifiers

PMID: 15507519
DOI: 10.1152/physiolgenomics.00204.2004
PMCID: PMC2556054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Altered specificity of Hint-W123Q supports a role for Hint inhibition by ASW in avian sex determination.PMID 15507519Read ↗

Feminizing chicks: a model for avian sex determination based on titration of Hint enzyme activity and the predicted structure of an Asw-Hint heterodimerSemantic proximity Read ↗

Sex Determination in Birds: <i>HINT</i>s from the W Sex Chromosome?Semantic proximity Read ↗

Gene conversion drives the evolution of HINTW, an ampliconic gene on the female-specific avian W chromosome.Semantic proximity Read ↗

Zygosity-based sex determination in a butterfly drives hypervariability of Masculinizer.Semantic proximity Read ↗

Towards a better understanding of the substrate specificity of the UDP-N-acetylglucosamine C4 epimerase WbpP.Semantic proximity Read ↗

Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila.Semantic proximity Read ↗

Acquisition of a leucine zipper motif as a mechanism of antimorphy for an allele of the Drosophila Hox gene Sex combs reduced.Semantic proximity Read ↗

Isolation of compensatory inhibitor domain mutants to novel activation domain variants using the split-ubiquitin screen.Semantic proximity Read ↗

The switch I and II regions of MinD are required for binding and activating MinC.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.