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Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities

26 Oct 2004

Abstract excerpt

We show that common heterochromatin antigenic protein markers [HP1alpha, -beta, -gamma and mono-, di-, and trimethylated histone H3 lysine 9 (H3K9)], although present in human blood progenitor CD34+ cells, differentiated lymphocytes, and monocytes, are absent in neutrophil granulocytes and to large extent, in eosinophils. Monomethylated and in particular, dimethylated H3K9 are present to variable degrees in the...

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PMID: 15507473
DOI: 10.1189/jlb.0704388

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