Article
Downregulation of circadian clock genes in chronic myeloid leukemia: alternative methylation pattern of hPER3.
Cancer science - 1 Dec 2006
Yang Ming-Yu, Chang Jan-Gowth, Lin Pai-Mei, Tang Kai-Ping, Chen Yen-Hsu, Lin Hugo You-Hsien, Liu Ta-Chih, Hsiao Hui-Hua, Liu Yi-Chang, Lin Sheng-Fung
Abstract excerpt
Disruption of circadian rhythm is believed to play a critical role in cancer development. To gain further insights into the roles of circadian genes in chronic myeloid leukemia (CML), we analyzed peripheral blood from 53 healthy individuals and 35 CML patients for the expression of the nine circadian genes. The expression levels of hPER1, hPER2, hPER3, hCRY1, hCRY2 and hBMAL1 were significantly impaired in both...
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