Article
Differential maintenance of the M184V substitution in the reverse transcriptase of human immunodeficiency virus type 1 by various nucleoside antiretroviral agents in tissue culture.
Antimicrobial agents and chemotherapy - 1 Nov 2004
Petrella Marco, Oliveira Maureen, Moisi Daniela, Detorio Mervi, Brenner Bluma G, Wainberg Mark A
Abstract excerpt
The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase (RT) is rapidly selected in tissue culture following serial passage of wild-type virus in the presence of increasing concentrations of lamivudine (3TC). M184V is also associated with several alterations of RT enzymatic function in vitro that may adversely affect viral fitness or replication capacity, which creates a potential...
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