Differential effects of S6 mutations on binding of quinidine and 4-aminopyridine to rat isoform of Kv1.4: common site but different factors in determining blockers' binding affinity.

Abstract excerpt

Quinidine and 4AP are two nonspecific K channel blockers. Both block voltage-gated K channels from the intracellular side of the membrane and, in most cases, binding is facilitated by channel activation. However, there are distinct differences between quinidine and 4AP in the time- and voltage-dependencies of drug-channel interaction. To learn about the molecular basis underlying the similarities as well as...

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