Article
Differential effects of S6 mutations on binding of quinidine and 4-aminopyridine to rat isoform of Kv1.4: common site but different factors in determining blockers' binding affinity.
The Journal of pharmacology and experimental therapeutics - 1 Oct 1998
Zhang H, Zhu B, Yao J A, Tseng G N
Abstract excerpt
Quinidine and 4AP are two nonspecific K channel blockers. Both block voltage-gated K channels from the intracellular side of the membrane and, in most cases, binding is facilitated by channel activation. However, there are distinct differences between quinidine and 4AP in the time- and voltage-de...
Topics
- 4-Aminopyridine
- Animals
- Binding Sites
- Female
- Ion Channel Gating
- Kv1.4 Potassium Channel
- Mutation
- Potassium Channels
- Potassium Channels, Voltage-Gated
- Quinidine
- Rats
- Structure-Activity Relationship
- Xenopus