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Article

The effect of deep pore mutations on the action of phenylalkylamines on the Kv1.3 potassium channel.

British journal of pharmacology - 1 Jul 1999

Rauer H, Grissmer S

Abstract excerpt

We investigated the action of the phenylalkylamines verapamil and N-methyl-verapamil on the Kv1.3 potassium channel using the whole-cell configuration of the patch-clamp technique. Our goal was to identify their binding as a prerequisite for using the phenylalkylamines as small, well-defined molecular probes, not only to expand the structural findings made with peptide toxins or by crystallization, but also to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10455250
DOI: 10.1038/sj.bjp.0702599
PMCID: PMC1566106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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The effect of deep pore mutations on the action of phenylalkylamines on the Kv1.3 potassium channel.PMID 10455250Read ↗

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