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Article

A novel role for protein kinase Gcn2 in yeast tolerance to intracellular acid stress.

The Biochemical journal - 1 Jan 2012

Hueso Guillem, Aparicio-Sanchis Rafael, Montesinos Consuelo, Lorenz Silvia, Murguía José R, Serrano Ramón

Abstract excerpt

Intracellular pH conditions many cellular systems, but its mechanisms of regulation and perception are mostly unknown. We have identified two yeast genes important for tolerance to intracellular acidification caused by weak permeable acids. One corresponded to LEU2 and functions by removing the dependency of the leu2 mutant host strain on uptake of extracellular leucine. Leucine transport is inhibited by...

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Identifiers

PMID: 21919885
DOI: 10.1042/BJ20111264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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