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Article

Bidirectional transcriptional activity of the Pgk1 promoter and transmission ratio distortion in Capn3-deficient mice.

Genomics - 1 Sept 2004

Taveau Mathieu, Stockholm Daniel, Marchand Sylvie, Roudaut Carinne, Le Bert Marc, Richard Isabelle

Abstract excerpt

A calpain 3 (Capn3) deficiency model was created by targeted disruption of the mouse Capn3 gene through homologous recombination in ES cells. Analysis of the genotype of pups from heterozygous crosses revealed a transmission ratio distortion (TRD) in favor of homozygous Capn3-deficient mice. This TRD was not observed in a second model of Capn3 deficiency, ruling out a possible involvement of Capn3 deficiency in...

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Source

Identifiers

PMID: 15498466
DOI: 10.1016/j.ygeno.2004.04.011

Genes

TRD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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