Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Branch site haplotypes that control alternative splicing

20 Oct 2004

Abstract excerpt

We show that the allele-dependent expression of transcripts encoding soluble HLA-DQbeta chains is determined by branchpoint sequence (BPS) haplotypes in DQB1 intron 3. BPS RNAs associated with low inclusion of the transmembrane exon in mature transcripts showed impaired binding to splicing factor 1 (SF1), indicating that alternative splicing of DQB1 is controlled by differential BPS recognition early during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA and protein synthesis mechanisms
Share to RNA Research and Splicing
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15496424
DOI: 10.1093/hmg/ddh334

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Branch site haplotypes that control alternative splicingPMID 15496424Read ↗

Phenotypic consequences of branch point substitutions.Semantic proximity Read ↗

Assessment of branch point prediction tools to predict physiological branch points and their alteration by variantsSemantic proximity Read ↗

Allele-specific recognition of the 3' splice site of INS intron 1.Semantic proximity Read ↗

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cellsSemantic proximity Read ↗

Precursor RNA structural patterns at SF3B1 mutation sensitive cryptic 3’ splice sitesSemantic proximity Read ↗

Novel α-Globin Splice Site Mutation (HBA2: c.96-5C>A) in Combination with Three-Gene Deletion Hb H Disease.Semantic proximity Read ↗

The dual effect of the lupus-associated polymorphism rs10516487 on BANK1 gene expression and protein localization.Semantic proximity Read ↗

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage.Semantic proximity Read ↗

Cryptic splicing sites are differentially utilized in vivo.Semantic proximity Read ↗

Structural basis for recognition of the intron branch site RNA by splicing factor 1.Semantic proximity Read ↗

Recognition of RNA Branch Point Sequences by the KH Domain of Splicing Factor 1 (Mammalian Branch Point Binding Protein) in a Splicing Factor ComplexSemantic proximity Read ↗

A deep intronic mutation in FGB creates a consensus exonic splicing enhancer motif that results in afibrinogenemia caused by aberrant mRNA splicing, which can be corrected in vitro with antisense oligonucleotide treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.