Article
[Gene inactivation in Mycobacterium tuberculosis and its use in tuberculosis control and prevention].
Biomedica : revista del Instituto Nacional de Salud - 1 Jun 2004
Chacón Ofelia, Realpe Teresa, Barletta Raúl Gerardo, Robledo Jaime
Abstract excerpt
Availability of the M. tuberculosis genome sequence and the development of sophisticated systems for genetic manipulation of bacilli offer the potential for new and effective tools to prevent and control tuberculosis. Efficient methods to inactivate mycobacterial genes have been developed. These methods have become the cornerstone for the application and development of mycobacterial functional genomics. Specific...
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