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Article

Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors

1 Feb 2009

Abstract excerpt

Differentiation is a complex set of events that can be blocked by rearrangements of regulatory genes producing fusion proteins with altered properties. In the case of myxoid liposarcoma (MLS) tumors, the causative abnormality is a fusion between the CHOP transcription factor and the FUS or EWS genes. CHOP belongs to and is a negative regulator of the large CAAT/enhancer binding protein family whose alpha, beta,...

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PMID: 19190116
DOI: 10.1158/1535-7163.mct-08-0848

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Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumorsPMID 19190116Read ↗

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Expression of the FUS-CHOP Fusion Protein in Primary Mesenchymal Progenitor Cells Gives Rise to a Model of Myxoid LiposarcomaSemantic proximity Read ↗

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