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Article

Comparable transforming capacities and differential gene expression patterns of variant FUS/CHOP fusion transcripts derived from soft tissue liposarcomas.

Oncogene - 2 Sept 2004

Schwarzbach Matthias Heinrich Martin, Koesters Robert, Germann Anja, Mechtersheimer Gunhild, Geisbill Jochen, Winkler Stefanie, Niedergethmann Marco, Ridder Ruediger, Buechler Markus W, von Knebel Doeberitz Magnus, Willeke Frank

Abstract excerpt

The chromosomal translocation t(12;16)(q13;p11) is a common genetic alteration in myxoid and round-cell liposarcomas. It results in transcription of various chimeric FUS/CHOP fusion transcripts that encode different oncogenic proteins. Recent reports suggest that these may have different neoplastic transformation activities. To audit this hypothesis, we transfected expression plasmids for the two major variant...

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Share to CCAAT-Enhancer-Binding Proteins
Share to Chromosomes, Human, Pair 12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15286712
DOI: 10.1038/sj.onc.1207840

Genes

FUS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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