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Article

Contribution of engineered electrostatic interactions to the stability of cytosolic malate dehydrogenase.

Protein engineering - 1 Nov 2001

Trejo F, Gelpí J L, Ferrer A, Boronat A, Busquets M, Cortés A

Abstract excerpt

Protein engineering is a promising tool to obtain stable proteins. Comparison between homologous thermophilic and mesophilic enzymes from a given structural family can reveal structural features responsible for the enhanced stability of thermophilic proteins. Structures from pig heart cytosolic and Thermus flavus malate dehydrogenases (cMDH, Tf MDH), two proteins showing a 55% sequence homology, were compared...

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PMID: 11742111
DOI: 10.1093/protein/14.11.911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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