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TKSA-MC: A web server for rational mutation through the optimization of protein charge interactions.

Proteins - 1 Nov 2018

Contessoto Vinícius G, de Oliveira Vinícius M, Fernandes Bruno R, Slade Gabriel G, Leite Vitor B P

Abstract excerpt

The TKSAMC is a web server which calculates protein charge-charge interactions via the Tanford-Kirkwood Surface Accessibility model with the Monte Carlo method for sampling different protein protonation states. The optimization of charge-charge interactions via directed mutations has successfully enhanced the thermal stability of different proteins and could be a key to protein engineering improvement. The server...

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PMID: 30218467
DOI: 10.1002/prot.25599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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