Article
ADR1c mutations enhance the ability of ADR1 to activate transcription by a mechanism that is independent of effects on cyclic AMP-dependent protein kinase phosphorylation of Ser-230.
Molecular and cellular biology - 1 Apr 1992
Denis C L, Fontaine S C, Chase D, Kemp B E, Bemis L T
Abstract excerpt
Four ADR1c mutations that occur close to Ser-230 of the Saccharomyces cerevisiae transcriptional activator ADR1 and which greatly enhance the ability of ADR1 to activate ADH2 expression under glucose-repressed conditions have been shown to reduce or eliminate cyclic AMP-dependent protein kinase (cAPK) phosphorylation of Ser-230 in vitro. In addition, unregulated cAPK expression in vivo blocks ADH2 depression in...
Topics
- Amino Acid Sequence
- DNA Mutational Analysis
- DNA-Binding Proteins
- Fungal Proteins
- Models, Genetic
- Molecular Sequence Data
- Peptides
- Phenotype
- Phosphorylation
- Protein Kinases