Article
Promoter binding by the Adr1 transcriptional activator may be regulated by phosphorylation in the DNA-binding region.
PloS one - 15 Sept 2008
Kacherovsky Nataly, Tachibana Christine, Amos Emily, Fox David, Young Elton T
Abstract excerpt
BACKGROUND: Post-translational modification regulates promoter-binding by Adr1, a Zn-finger transcriptional activator of glucose-regulated genes. Support for this model includes the activation of an Adr1-dependent gene in the absence of Adr1 protein synthesis, and a requirement for the kinase Snf1 for Adr1 DNA-binding. A fusion protein with the Adr1 DNA-binding domain and a heterologous activation domain is...
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