Article
Cyclic AMP-dependent protein kinase inhibits ADH2 expression in part by decreasing expression of the transcription factor gene ADR1.
Molecular and cellular biology - 1 Mar 1997
Dombek K M, Young E T
Abstract excerpt
In Saccharomyces cerevisiae, the unregulated cyclic AMP-dependent protein kinase (cAPK) activity of bcy1 mutant cells inhibits expression of the glucose-repressible ADH2 gene. The transcription factor Adr1p is thought to be the primary target of cAPK. Here we demonstrate that the decreased abunda...
Topics
- Alcohol Dehydrogenase
- Binding Sites
- Cyclic AMP-Dependent Protein Kinases
- DNA-Binding Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Mutation
- Phosphorylation
- Promoter Regions, Genetic
- RNA, Fungal
- RNA, Messenger
- Recombinant Fusion Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sequence Deletion
- Serine
- Transcription Factors
- Transcription, Genetic