Article
International Union of Pharmacology. LX. Retinoic acid receptors.
Pharmacological reviews - 1 Dec 2006
Germain Pierre, Chambon Pierre, Eichele Gregor, Evans Ronald M, Lazar Mitchell A, Leid Mark, De Lera Angel R, Lotan Reuben, Mangelsdorf David J, Gronemeyer Hinrich
Abstract excerpt
Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARalpha, RARbeta, and RARgamma), members of the nuclear hormone receptor superfamily. The most important endogenous retinoid is all-trans-retinoic acid. Retinoids regulate a wide variety of essential biological processes, such as vertebrate embryonic morphogenesis and organogenesis, cell growth arrest, differentiation and...
Topics
- Animals
- Binding, Competitive
- Gene Expression
- Humans
- Mutation
- Neoplasms
- Receptors, Retinoic Acid
- Retinoids
- Skin Diseases
- Tretinoin
