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Article

Differential mutagenicity of riddelliine in liver endothelial and parenchymal cells of transgenic big blue rats.

Cancer letters - 25 Nov 2004

Mei Nan, Chou Ming W, Fu Peter P, Heflich Robert H, Chen Tao

Abstract excerpt

Riddelliine is a naturally occurring pyrrolizidine alkaloid that induces liver hemangiosarcomas in rats and mice. We previously reported higher levels of DNA adducts in liver endothelial cells than in liver parenchymal cells of riddelliine-treated mice and rats [Cancer Lett. 193 (2003) 119], suggesting that the tumor specificity is due to higher levels of DNA damage in the cells that form hemangosarcomas. In the...

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Identifiers

PMID: 15488633
DOI: 10.1016/j.canlet.2004.06.013
PMCID: PMC6370022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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