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Article

The cowpox virus fusion regulator proteins SPI-3 and hemagglutinin interact in infected and uninfected cells.

Virology - 30 Mar 2006

Turner Peter C, Moyer Richard W

Abstract excerpt

The serpin SPI-3 and the hemagglutinin (HA) encoded by cowpox virus (CPV) block cell-cell fusion, and colocalize at the cell surface. wtCPV does not fuse cells, but inactivation of either gene leads to fusion. SPI-3 mAb added to wtCPV-infected cells caused fusion, confirming that SPI-3 protein at the cell surface prevents fusion. The SPI-3 mAb epitope mapped to an 85-amino acid region at the C-terminus. Removal...

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Identifiers

PMID: 16378629
DOI: 10.1016/j.virol.2005.11.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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