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Article

Vaccinia virus induces cell fusion at acid pH and this activity is mediated by the N-terminus of the 14-kDa virus envelope protein.

Virology - 1 Sept 1990

Gong S C, Lai C F, Esteban M

Abstract excerpt

The mechanism by which the large-size poxviruses enter animal cells is not known. In this investigation we show that acid pH treatment of wild-type vaccinia virus-infected cells triggers strong fusion of cells in culture, with an optimum at pH 4.8. We have identified the virus-induced fusion prot...

Topics

Amino Acid Sequence
Animals
Base Sequence
Chromosome Mapping
DNA, Viral
Hydrogen-Ion Concentration
Membrane Fusion
Mice
Molecular Sequence Data
Mutation
Vaccinia
Vaccinia virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Envelope Proteins

Source

Identifiers

PMID: 2389560
DOI: 10.1016/0042-6822(90)90381-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2389560-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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