Article
Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation.
Journal of hepatology - 1 Apr 2007
Kremer-Tal Sigal, Narla Goutham, Chen Yingbei, Hod Eldad, DiFeo Analisa, Yea Steven, Lee Ju-Seog, Schwartz Myron, Thung Swan N, Fiel Isabel M, Banck Michaela, Zimran Eran, Thorgeirsson Snorri S, Mazzaferro Vincenzo, Bruix Jordi, Martignetti John A, Llovet Josep M, Friedman Scott L
Abstract excerpt
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) has the most rapidly rising cancer incidence in the US and Europe. The KLF6 tumor suppressor is frequently inactivated in HCC by loss-of-heterozygosity (LOH) and/or mutation. METHODS: Here we have analyzed 33 HBV- and 40 HCV-related HCCs for mRNA expression of wildtype KLF6 (wtKLF6) as well as the KLF6 variant 1 (SV1), a truncated, growth-promoting variant that...
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