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Article

Functional expression of the pore forming subunit of the ATP-sensitive potassium channel in Saccharomyces cerevisiae.

Biochemical and biophysical research communications - 7 Jun 2000

Graves F M, Tinker A

Abstract excerpt

We have expressed the pore-forming subunits (Kir 6.1 and Kir 6.2) of the mammalian ATP-sensitive potassium channel in a potassium-transport deficient yeast strain (trk1 trk2). Functional expression of Kir 6.2 and Kir 6.1 can complement growth deficiency weakly and strongly respectively of the yeast strain on low-potassium medium. Mutations of Kir 6.2 that abolish ATP sensitivity (K185Q, I182Q) and enhance...

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Identifiers

PMID: 10833427
DOI: 10.1006/bbrc.2000.2798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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