Epigenetics and human disease.

doi:10.1146/annurev.genom.5.061903.180014

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Article

Epigenetics and human disease.

Annual review of genomics and human genetics - 1 Jan 2004

Jiang Yong-Hui, Bressler Jan, Beaudet Arthur L

Abstract excerpt

Epigenetics is comprised of the stable and heritable (or potentially heritable) changes in gene expression that do not entail a change in DNA sequence. The role of epigenetics in the etiology of human disease is increasingly recognized with the most obvious evidence found for genes subject to genomic imprinting. Mutations and epimutations in imprinted genes can give rise to genetic and epigenetic phenotypes,...

Topics

Alleles
Chromatin
DNA Methylation
Diet
Epigenesis, Genetic
Female
Gene Expression
Genetic Diseases, Inborn
Genomic Imprinting
Humans
Male
Models, Genetic
Pedigree

Source

Open in PubMed

Identifiers

PMID: 15485357
DOI: 10.1146/annurev.genom.5.061903.180014

Provenance

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